This quote gives insight on Brabantio's feelings towards his daughter. It basically comes out and says that he is ashamed off his daughter for running off and marrying Othello, someone of differnet color. He speaks of how she let down the nation and how he is trying to pin all this conflict on.
This quote can be connected to a larger theme, because it has to do with racism. Even though Othello is of a differnt racial status than Desdamona he is a very well respected man of higher authority and Brabantio can not accept that at this point in time.
"That thou hast practiced on her with foul charms"
practiced on her- meaning -- tricked her.
Do you think that Brabantio will ever open up to accepting Desdamona's marriage?
Why do you think that Brabantio is trying to blame his daughter for the war?